| 1619 | Enslaved Africans brought to Jamestown, Virginia. |
| 1641 | Massachusetts legally recognizes slavery. |
| 1662 | Virginia law determines status of children will be same as that of the mother. |
| 1684 | Ship Isabella brings150 enslaved Africans to Philadelphia. |
| 1705 | Virginia law determines imported servants who were not Christians in native country are slaves; slaves are chattel property, and may be disciplined or killed without penalty. |
| 1780 | Pennsylvania passes the Gradual Abolition Act prohibiting importation of enslaved Africans into the state and guarantees future children of enslaved Pennsylvania mothers will be born free but indentured until age twenty-eight. |
| 1783 | Massachusetts abolishes slavery. |
| 1787 | Transporting enslaved persons into the Northwest Territory is banned. |
| 1787 | The Constitution states that Congress may not interfere with the slave trade until 1808. Pennsylvania legislature amends1780 Gradual Abolition Act; prohibits transportation of a pregnant enslaved woman out of state (so the child would be born enslaved) or separation of enslaved family members by more than ten miles; requires registration of the child of an enslaved mother within 6 months of birth. |
| 1791 | Washington circumvents law by transporting enslaved servants out of state before six-month residency in Pennsylvania. |
| 1793 | Fugitive Slave Act reinforces the Constitutional right of a slaveholder to recover a runaway slave. |
| 1794 | Slave Trade Act makes it illegal for American ships to engage in the slave trade and to sell enslaved people abroad. |
| 1808 | Children born after 1780 to enslaved Pennsylvania mothers are freed of their indentures under the 1780 Gradual Abolition Act. |
| 1808 | Congress bans international slave trade; smuggling continues. |
| 1820 | Missouri Compromise establishes boundaries of slavery in Louisiana Purchase territory. |
| 1847 | Pennsylvania legislature frees all enslaved in the state. |
| 1850 | Compromise of 1850 makes it easier for slaveholders to retrieve escapees. |
| 1851 | Largest trial for treason in U.S. history occurs in Philadelphia. Thirty-eight black and white Pennsylvanians attempt to prevent the seizing of suspected runaway slaves in Pennsylvania. One is found not guilty; charges against the rest are dismissed. |
| 1857 | Dred Scott Supreme Court decision rules Congress may not ban slavery in states or territories, and African Americans are not citizens. |
| 1860 | Federal census counts almost four million enslaved in the U.S. |
| 1863 | President Abraham Lincoln issues Emancipation Proclamation. |
| 1865 | The Thirteenth Amendment to abolishes slavery in the U.S. |